Three Sisters is a roll-and-write strategy game with a gardening theme. Its name comes from a technique used by the indigenous people of North America that is still used today. Specifically, pumpkin, corn, and beans are planted together in very close proximity. The corn provides support for the beans to "climb," which in turn transfer nitrogen from the air to the soil, and the pumpkin repels weeds and pests.

In the game, you are called to take care of your gardens and plants over the course of 8 rounds. Water, plant, fertilize, and visit the Market for new seeds and supplies. The player with the most points wins the game!