In a very distant future, a psychic hormone discovered in the human brain granted people extra-sensory powers, changing the world as we know it.

As humanity entered this new era, the deranged mutants known as "Others" began descending from the sky, thirsting for human brains. Resistant to conventional attack methods, extreme measures were needed to combat the overwhelming threat and preserve humanity. Those with extra-sensory abilities, known as Psychics, became the opportunity to fight back from above. Up until now, Psychics have been identified for their talents and recruited into the Other Suppression Force (OSF), humanity's last line of defense.

Take on the role of Yuito Sumeragi, a newcomer to the OSF who aims to become a top-ranking Psychic like the one who saved him as a child. Armed with the talent of telekinesis, explore the futuristic city of New Himuka and uncover the mysteries of a Brain Punk future trapped between technology and psychic abilities in SCARLET NEXUS.