From the ashes of old conflicts, a new horror is born. The Umbrella Corporation and its crop have been destroyed by deadly viruses. Yet another new, more dangerous threat has emerged.

Years after the devastating events in Raccoon City, Chris Redfield fights against bio-organic weapons across the globe. Now a member of the Bioterrorism Security Assessment Alliance (BSAA), Chris is sent to Africa to investigate a biological agent that is turning populations into aggressive and disturbing creatures. Teaming up with another local BSAA agent, Sheva Alomar, he must solve the mystery and uncover the truth behind the unsettling series of events.