The North American Jerry Drake, or Mr. No, is a fictional character from Italian comics created in 1975. He experienced many adventures throughout World War II, where he fought as a soldier, pilot, and member of American secret services in various locations. He was eventually named Mr. No by his comrades and adversaries due to his pride and stubborn refusal to obey orders. In early 1945, he returned home. Exhausted from the war's mistakes, disgusted by the violence of the Western world, and completely unable to adapt to a normal life in his homeland, he decided to settle in Manaus, Brazil to live life on his own terms, in a place that some people call the last frontier of civilization.

Jerry Drake takes on a new mission in the depths of the Amazon with a group of scientists, aiming to convince the indigenous tribe that they are threatened by a deadly danger. And while he tries to persuade the natives to abandon their land, mysterious figures appear in his path. Once again, he will have to fight to survive...